The major advantage of pregabalin is its relative reliability, easy use and high tolerance in patients with neuropathic pain. Clinical studies have also shown the efficacy and dose dependent effects of pregabalin either as monotherapy or in combination with analgesics in relieving pain and related symptoms. Animal based studies have helped to describe the mechanisms for its anti-hyperalgesic and anti-allodynic action. Preclinical and clinical studies have shown the effectiveness of pregabalin in managing the neuropathic pain. In fact pregabalin is the first drug to receive an approved labeling from Food and Drug Association (FDA) for the treatment of diabetic neuropathy and post-herpetic neuralgia. It is a well established anticonvulsant and analgesic agent. Pregabalin, (S)-3-(aminomethyl)-5-methylhexanoic acid, is a pharmacologically active S-enantiomer of a racemic 3-isobutyl gamma amino butyric acid analogue. This may also develop secondary to some other pathological conditions such as diabetes mellitus, cancer, herpes infection, autoimmune diseases and HIV infection etc. Neuropathic pain is a result of various mechanisms operating at the peripheral, spinal cord and supra-spinal levels, which cause alterations in the pain conduction pathway. Spontaneous pain may be simply conceptualized as вЂњstimulus independentвЂќ whereas hyperalgesia and allodynia as вЂњstimulus dependentвЂќ.

the gentle touch of clothes, bending of cutaneous hairs by a puff of wind). Hyperalgesia is an increased pain response to supra-threshold noxious stimulus, while allodynia is a sensation pain elicited by a non noxious stimulus (e.g. Spontaneous pain is characteristically burning or shooting in nature. Spontaneous pain, hyperalgesia and allodynia are the common symptoms observed in neuropathic pain. It involves alterations in the function, chemistry and structure of neurons. In other words, neuropathic pain may be defined as the pain originated from the pathology of the nervous system. Neuropathic pain as defined by The International Association for the Study of Pain is вЂњpain initiated or caused by a primary lesion in the nervous systemвЂќ. Preclinical and clinical studies as well as focuses on the possible mechanisms. The present review summarizes the important aspects of pregabalin as analgesic in

Release, activation of excitatory amino acid transporters (EAATs), potassium channels and inhibition of pathways Have explored various molecular targets and the signaling systems including Ca2+ channel-mediated neurotransmitter Preclinical studies employing pregabalin in different neuropathic pain models

Preclinical studies in variousДЄnimal models of neuropathic pain have shown its effectiveness in treating the symptoms like allodynia and hyperalgesia.Д¬linical studies in different age groups and in different types of neuropathic pain (peripheral diabetic neuropathy,ДЇibromyalgia, post-herpetic neuralgia, cancer chemotherapy-induced neuropathic pain) have projected it as the mostД®ffective agent either as monotherapy or in combined regimens in terms of cost effectiveness, tolerability and overall It successfully alleviates the symptoms of various types of neuropathic painДЄnd presents itself as a first line therapeutic agent with remarkable safety and efficacy. Produce antiepileptic and analgesic actions. Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-2-delta subunit to

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